Nose Cartilage Helps Knee Osteoarthritis

Did you know your nose could help your knees.  Find out how next…

Aching Knee? Surgeons Pioneer Groundbreaking New Operation Taking Tissue From The NOSE To Grow Cartilage That May Be Due To Osteoarthritis!

Roger Dobson writing for the Daily Mail reported surgeons are taking tissue from the nose to grow cartilage to fix knee-joint pain.
The operation sees cartilage harvested from the nose, which is then used to grow patches of tissue to be transplanted on to knee joints.

The procedure is regarded as particularly beneficial for osteoarthritis patients, or those at risk of the joint disease, and doctors carrying out the operation say it could help thousands of people.

The most widely used procedure to repair the injury involves trimming any remaining damaged tissue and drilling holes in the bone beneath the defect to trigger bleeding and scar tissue that, it is hoped, can work as a substitute tissue.

But according to the NHS, results are variable, with studies suggesting that it offers only short-term benefits and does not lead to the formation of new cartilage.

Comment: The procedure is a bit risky for only short term relief but maybe it will improve.

For more information on regrowing cartilage for knee osteoarthritis, click this link:


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Mediterranean Diet Prevents Disease

Could diet cure your ailments? Maybe… next

Mediterranean Diet May Reduce Incidence Of Certain Diseases, Study Suggests

Jacqueline Howard writing for CNN reported new research suggests that a Mediterranean diet rich in “healthy” fats may reduce the risk of incidence of “heart disease, breast cancer and type 2 diabetes.” For the meta-analysis, researchers reviewed 332 previous studies and analyzed around 56 of them, “taking a close look at the health benefits of a Mediterranean diet that included a lot of fat.” The findings, published in the Annals of Internal Medicine, “showed that even though such a diet may not affect overall mortality, it may be effective at reducing incidences of certain diseases.”

Comment: Diet is often overlooked when it comes to disease treatment. It is extremely important… maybe more than we think.

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Stem Cells for Hip Osteoarthritis

Hope for young people with bad osteoarthritis of the hips… next

Stem Cells Could Replace Hip Replacements

Christopher Wanjek writing for Live science reported scientists have coaxed stem cells to grow new cartilage on a scaffold shaped like the ball of a hip joint. This is a major step toward being able one day to use a patient’s own cells to repair a damaged joint, thus avoiding the need for extensive joint-replacement surgery.

In addition, the scientists used gene therapy to grant this new cartilage the ability to release anti-inflammatory molecules when needed. If done in patients, this technique could help prevent a return of arthritis, if that was what damaged the joint in the first place.

The new technique may be ready to test in humans within three to five years and may ultimately work with other joints, such as knees, said Farshid Guilak, a professor of orthopedic surgery at Washington University School of Medicine in St. Louis, who co-led the project.

Comment: We stopped doing stem cell procedures for hips at our center because we weren’t getting the results we wanted. While this approach looks like it might work I’m reserving judgement. The hip has a unique mechanical structure that makes any type of stem cell procedure problematic..

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Fibromyalgia Worsens Psoriatic Arthritis

Fibromyalgia… it’s more than just minor aches and pains

Fibromyalgia Worsens Psoriatic Arthritis Outcomes

Caitlyn Fitzpatrick writing in MD reported on a recent study. Published in The Journal of Rheumatology, the researchers looked at 73 patients with psoriatic arthritis. Forty-two participants (57.5%) were females and the average age was nearly 52. Clinical disease activity was measured using multiple different scales.   Also, using the American College of Rheumatism criteria, fibromyalgia was diagnosed in 13 patients (17.8%) – 12 of which were female.

Twenty-six patients (43.3%) with just psoriatic arthritis met the criteria for minimal disease activity, however, none of the participants who had fibromyalgia did.

The big takeaway here is that the presence of fibromyalgia worsened all psoriatic arthritis disease activity scores.

Comment: Not surprising.  The association of fibromyalgia with all forms of inflammatory arthritis is not a good combination.

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Gel Relieves Ostoearthritis

Wow… a new development that may help erase osteoarthritis… next

Unique Gel Combats Inflammation

Jessa Gamble writing for the Atlantic reported researchers have created a gel that can attach to inflammation sites and slowly deliver drugs to combat a wide variety of ailments—ulcerative colitis, arthritis and mucositis, to name a few. Inflammation is part of the body’s immune response, bringing extra blood to an injured area, but in cases of chronic inflammation, the heat, pain, and swelling become a problem. Developed at the Laboratory for Accelerated Medical Innovation at the Brigham and Women’s Hospital, the hydrogel—a solid material with high water content—can carry a combination of drugs, and matches its drug release to the level of inflammation around it.

When the gel is injected into the joint of an arthritis patient, for example, it will only release its anti-inflammatory payload when the patient is experiencing a flare, a spike in pain and swelling. When it encounters healthy tissue, it stays intact and does not release its payload.

“There are lots of enzymes present in inflammation that can degrade the gel,” explains Jeff Karp, the principal investigator. That breakdown of the gel releases the drug it carries.

Comment: This looks promising… Stay tuned.

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Anxiety Reduces Response to Methotrexate

One very important determinant of response to methotrexate…

Anxiety Prior To Methotrexate Therapy May Result In Non-Response At 6 Months

Reported in Healio… patients with rheumatoid arthritis who experience anxiety prior to the start of methotrexate therapy may have non-response at 6 months due to poor adherence, according to results presented at the EULAR Annual Congress.

“From a long list of lifestyle, clinical and psychosocial predictors at baseline, BMI, smoking and DAS28 score were each shown to significantly predict non-response 6 months after patients had started treatment with methotrexate,” Suzan Verstappen, of the Centre for Musculoskeletal Research at the University of Manchester, United Kingdom, said in a press release. “Of particular interest, however, is the role of participant anxiety on starting treatment with methotrexate in predicting response, which is likely to be the result of its negative effect on adherence.”

Comment: the mind is a powerful influence

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Rheumatoid Arthritis and Gout Diverging

One arthritis disease is leading to more hospitalizations and the other is causing fewer… next

Costs For Gout And Rheumatoid Arthritis

Reported in ET Health World …While hospitalizations related to rheumatoid arthritis have dropped considerably over the past two decades, hospitalizations primarily associated with gout have increased dramatically. These results of a study described in a research letter in JAMA reflect improved management of rheumatoid arthritis patients and both an increased prevalence and persistent suboptimal care of gout.

Comment: I’m not surprised. While getting RA patients into remission is easier, identifying and treating gout patients is getting harder. Much of that could be attributed to the obesity epidemic.

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Marriage Reduces Heart Attack Deaths

Another advantage of marriage… next

Being married may improve your odds of surviving a heart attack

Linda Carroll reported on Today, being married may improve the likelihood of surviving a heart attack, a new study finds. And patients who are married are more likely to have a shorter stay at the hospital after a heart attack, according to the study presented at the British Cardiovascular Society (BCS) Conference in Manchester, U.K.

Out of almost a million British men and women, about 25,000 had a heart attack, said study co-author Nicholas Gollop, a doctoral research fellow in cardiology at the Norfolk and Norwich University Hospital. Based on the findings, if patients were divided by marital status, the married ones were 14 percent more likely to be alive than singles by the end of the study. Singles didn’t suffer the worst of it, however. Divorced patients were 6 percent more likely to die during the seven to eight years of follow-up, compared to never marrieds.

Comment: If my wife hears about this, I’ll never hear the end of it.

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Rheumatoid Arthritis Patients Screen for Hearing Loss

Can you hear me now… maybe not if you have rheumatoid arthritis… next

Screening Rheumatoid Arthritis Patients for Hearing Impairments is Vital

Rachel Lutz writing for MD reported rheumatoid arthritis (RA) patients should be screened for hearing impairments.

Researchers from Odense University Hospital in Denmark TK evaluated published clinical reports related to hearing impairment in patients with RA. Additionally, they aimed to determine possible pathologies and associated factors as well as new treatment modalities for RA patients with auditory deficit.

Patients with RA are at a higher risk for having a hearing impairment compared to healthy subjects over the course of the disease, the researchers extrapolated. The team also reported that the hearing impairment in RA patients appears to be a multifactorial condition, but they were unable to determine the mechanism of the injury and the relative risk factors.  Some of the factors include smoking, alcohol and noise, which can all deteriorate hearing abilities, they said. For RA patients more specifically, long term alcohol exposure could affect hearing loss and impact the cochlear function over time.

Comment: Interesting.

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Pain Predictor of Knee Osteoarthritis

Are there early warning signs of knee arthritis? Yup!

Persistent knee pain predicts structural arthritis early.

Sara Freeman writing in Rheumatology news reported on a study that showed that persistent knee pain is in important predictor of structural joint damage and could potentially be used to predict knee osteoarthritis earlier according to Dutch research reported at the World Congress on Osteoarthritis. The analysis found that women participating in the Rotterdam study who had knee pain on most days of the preceding month were more than 4 times more likely to develop knee osteoarthritis within 5 years on MRI than were those without frequent knee pain.

Comment: a key finding.

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