NSAIDS may reduce risk for squamous cell carcinoma

Could NSAIDS be good for you?

NSAIDS may reduce risk for squamous cell carcinoma.

Nicholas Bakalar writing in the New York Times reported that research published in the Journal of Investigative Dermatology suggests that “aspirin and other nonsteroidal anti-inflammatory drugs taken orally may reduce the risk for squamous cell carcinoma.” Investigators came to this conclusion after analyzing “data from nine studies of various designs.”

Comment: Rheumatologists still have reluctance to prescribe NSAIDS because of the side effect profile but not all the news is bad.

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Body Weight Influence on Response to RA Treatment

Does weight have influence on the rate of  remission in RA?

Weight Could Influence Rheumatoid Arthritis Relief

Alex Kramer writing for Healthday reported people with rheumatoid arthritis may be more likely to achieve remission if they maintain a healthy body weight, according to new research.

The study found that those who were heaviest had almost 65 percent reduced odds of disease remission. Being underweight also lowered the odds of remission.

“Medication for rheumatoid arthritis is not as effective on the overweight population,” said Dr. Susan Goodman, the study’s lead author and a rheumatologist at the Hospital for Special Surgery in New York City.

Comment: Another mark against obesity.

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Link Between Rheumatoid Arthritis and Alzheimers

Is there a relationship between rheumatoid arthritis and Alzheimer’s disease.  The answer next…

Rheumatoid arthritis patients may also have increased risk for Alzheimer’s disease

Reported in Healio, Researchers from the Cleveland Clinic found patients with rheumatoid arthritis may have an increased risk of developing Alzheimer’s disease and other shared risk factors, according to a presentation at the American College of Rheumatology meeting. “These are two very common diseases, and perhaps the inflammatory burden may provide important clues to the pathogenesis of Alzheimer’s disease,” study author, M. Elaine Husni, MD, MPH, a rheumatologist and director of the Arthritis & Musculoskeletal Treatment Center at the Cleveland Clinic was quoted as saying.

Comment: Very disturbing news indeed.

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Surgery To Repair Meniscal Tears May Be Linked To Risk Of Arthritis

Does meniscus surgery protect you from getting osteoarthritis of the knee… the answer coming up


Surgery To Repair Meniscal Tears May Be Linked To Increased Risk Of Arthritis.

Robert Preidt writing in Healthday reported that research presented at the Radiological Society of North America meeting suggests that surgery to repair meniscal tears may be linked to an increased risk of arthritis. Investigators “used MRI scans to look at 355 knees with arthritis, and compared them to a similar number of knees without arthritis.” The researchers found that “all 31 knees that were operated on to repair meniscal tears developed arthritis within a year, compared with 59 percent of knees with meniscal damage that did not have surgery.” The study also found that “cartilage loss occurred in nearly 81 percent of knees that had meniscal surgery, compared with almost 40 percent of knees with meniscal damage that did not have surgery.”


Comment: Unless a meniscus tear is incapacitating it might be better to avoid surgery.


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Osteoarthritis Risk Factors Confirmed

What are the major risk factors for getting knee osteoarthritis?.  Find out next…

Familiar Risk Factors For Knee OA In Those Aged 50 Or More Confirmed In New Systematic Review And Meta-Analysis.

Wayne Kuznar writing in MedPage Today reported that “familiar risk factors for knee osteoarthritis (OA) in individuals 50 years and older – high body mass index (BMI), previous knee injury, age, female sex, and the presence of hand OA – were confirmed as the condition’s top drivers in a new systematic review and meta-analysis with an updated evidence base.” The findings were published in Osteoarthritis and Cartilage.


Comment: No surprises here.

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Studies: Family History Remains A Risk Factor For Arthritis.


Here’s a risk factor for arthritis you can’t do anything about… next

Studies: Family History Remains A Major Risk Factor For Arthritis.

Nancy Walsh writing in MedPage Today reported that “recent studies have confirmed that family history remains a major risk factor for arthritis.”

Research published in Annals of the Rheumatic Diseases indicated that “individuals who had a parent who had undergone knee replacement because of osteoarthritis (OA) subsequently experienced worsening knee pain.”

Comment: So go ahead… blame your mom or dad…

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TNF-Inhibitors May Cut Risk of Congestive Heart Failure in RA

Can you use TNF inhibitors if you have heart failure?

TNF-Inhibitors May Cut Risk of Congestive Heart Failure in RA

Kate Johnson writing for Medpage Today reported the risk of congestive heart failure (CHF) is reduced in rheumatoid arthritis (RA) patients taking anti-tumor necrosis factor (TNF) drugs compared with those receiving nonbiologic disease-modifying anti-rheumatic drugs (nbDMARDs), according to new research.

The findings may encourage rheumatologists who may have hesitated to prescribe anti-TNF therapy, said lead author Alper van Sijl of the ANIOS Interne Geneeskunde at Diakonessenhuis in Utrecht, the Netherlands.

Comment: Comforting since we have been reluctant to use these drugs in patients with heart failure.

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Regular marijuana users have shrunken brains

A significant hazard from pot smoking

Regular marijuana users have shrunken brains


Melissa Healy writing for the LA Times reported compared with a person who never smoked marijuana, someone who uses marijuana regularly has, on average, less gray matter in his orbital frontal cortex, a region that is a key node in the brain’s reward, motivation, decision-making and addictive behaviors network. The findings were reported in the journal PNAS.


Comment: Disturbing news indeed.


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Spider venom for osteoarthritic pain

Do you like spiders?  You may after this next post…

Spider venom for osteoarthritic pain

Rachel Worsley writing in Rheumatology Update reported painkillers based on spider venom may be a few years away from bringing relief to neuropathic and osteoarthritis pain sufferers, according to Queensland researchers.

Researchers led by Professor Glenn King from the University of Queensland have begun isolating unique peptides that could target voltage-gated sodium channel NaV1.7, a key player in the human pain signalling pathway.

Blocking that pathway could mean an end to all kinds of pain, including neuropathic and osteoarthritis pain.


Comment: Itsy bitsy spider went up the water spout…

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