A brand new treatment for osteoarthritis



A brand new treatment for osteoarthritis… next
New treatment could ease the agony of arthritis: Tiny bubbles made by the body’s own cells may slash the need for surgery

Fiona Macrae writing for the Daily Mail reported a bubble-based treatment that could ease the pain of arthritis and cut the need for hip replacements is being developed by British scientists.
It uses tiny particles that are naturally made by the body to protect and repair damaged joints.
This should mean that arthritis is better treated – reducing pain and improving movement of millions.
It may also cut the need for painful, complicated and expensive hip and knee replacement operations.
Scientists have discovered tiny bubbles called microvesicles, made by the body’s own cells, may ‘cure’ the cartilage of arthritis sufferers
The hope centres on microvessicles – tiny, fluid-filled bubbles made by the body’s cells.
Research at Queen Mary University of London has shown that the thick fluid that bathes the joints in arthritis sufferers is rich microvessicles that are battling against the disease.
These microvessicles are packed with a protein called Annexin A1 that protects the cartilage that lines and cushions the joints from arthritis.
In experiments on arthritic mice, an injection of the microvessicles into the joints reduced cartilage damage. Plus, arthritis was worse in mice that made lower than usual levels of these microvessicles.
The protein may even repair damage.

Comment: Exciting news indeed.


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Heart disease-related deaths among US rheumatoid arthritis patients declined



Good news for RA patients… next
Heart disease-related deaths among US rheumatoid arthritis patients declined
Evan Douglas
Evan Douglas writing in wwntradio reported heart disease-related deaths among US rheumatoid arthritis patients declined.
Rheumatoid arthritis patients are twice as likely as the average person to develop heart disease, but a new study shows that efforts to prevent heart problems and diagnose and treat heart disease early may be paying off. Despite the heightened danger, deaths from cardiovascular disease among people with rheumatoid arthritis are declining, the research found. The study by the Mayo clinic was presented at the American College of Rheumatology’s annual meeting.
Dr. Elena Myasoedova, lead author of the study, believes that further research should be done to confirm why cardiac deaths among patients with rheumatoid arthritis have dropped, but factors such as improved treatment for rheumatoid and cardiovascular diseases, early screening for heart problems and more attention to the heart health of patients have indeed influenced the drop.
Comment: this is really good news since it means our therapies are working not only on the joints but on the rest of the organ systems as well.


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Viscosupplement Knee Osteoarthritis Lubricin



Do lubricant injections work? Why is the data so unclear?

Osteoarthritis finding sheds new light on HA injection controversy

Reported in Eureka Alert, injections of hyaluronic acid (HA) are a common treatment of pain in osteoarthritis of the knee – a condition that affects 27 million Americans according to the Centers for Disease Control and Prevention. The injections replace natural HA that has depleted from one’s joints, which can cause pain and stiffness due to the lack of lubrication between bones moving against each other.

There are eight different HA products sold in the U.S And, while all of these products are approved by the FDA, studies have produced mixed results on their effectiveness, leading researchers and doctors to question how HA actually functions in the body.

A research group led by Lawrence Bonassar, professor of biomedical engineering, and graduate student Edward Bonnevie at Cornell University has discovered that another molecule, lubricin, helps anchor HA at the tissue surface, which, in turn, helps to move cartilage into a low-friction regime. “The implication of this finding is that the efficacy of HA treatment might depend on how much lubricin is in the joint at the time of injection, which could explain why clinical trials of HA have such variable outcomes and may also suggest new formulations of HA that might be even more effective in the clinic,” said Bonassar. The study was published in the journal PLOS ONE.

Comment: Very interesting


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Pomegranate Benefits



 

Pomegranates.. . what’s the latest?

Pomegranates: Other Benefits Besides Arthritis Treatment

By Breana Noble   |   Thursday, 15 Oct 2015 03:24 PM

Breanna Noble reporting in Newsmax wrote people have long associated the pomegranate, a fruit native to Persia, with health, fertility, and eternal life in legend and mythology.

The healthful benefits of the pomegranate, however, may not be so fictional. In addition to helping with the symptoms of arthritis, the fruit may also work wonders for heart and blood diseases and cancers, according to Dr. Joel Fuhrman.

Studies have shown that pomegranates contain the most of every type of antioxidant over other fruits, such as strawberries and blueberries. Antioxidants are important for keeping a strong immune system and combating inflammation.

Unique to the fruit is a component called punicalagin, which is beneficial to heart and blood health, according to Fuhrman. The compound has shown to decrease blood pressure as well as increase the rate at which the body removes atherosclerosis, or heart blockages.

Pomegranates seem to also have anti-inflammatory and anti-cancer effects. “The use of juice, peel and oil have also been shown to possess anticancer activities, including interference with tumor cell proliferation, cell cycle, invasion and angiogenesis,” in the Journal of Ethnobiology.. “These may be associated with plant based anti-inflammatory effects.”

Comment: the latest in achieving benefit from natural ingredients.


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Cardiovascular disease cause of mortality among patients with RA


What’s the primary cause of death in patients with rheumatoid arthritis…next

Cardiovascular disease remains leading cause of mortality among patients with RA

From Healio, results of a recently published study identified cardiovascular disease as the leading cause of death among patients with rheumatoid arthritis in São Paulo, Brazil, and highlighted infectious disease as an emerging cause of rheumatoid arthritis-associated death.

Pinheiro and colleagues reported in the Journal of rheumatology these findings… they studied 3,629,559 death certificates issued in São Paulo issued between 1996 and 2010 and identified 3,955 that listed death related to rheumatoid arthritis (RA). Of these, 1,095 certificates listed RA as the underlying cause of death and 2,860 certificates listed the condition as the non-underlying cause of death.

Death occurred after age 50 years in 90% of patients with RA. Seventeen patients were younger than 20 years at the time of their deaths, with four patients having RA as the listed underlying cause of death. The mean age of death was 67.1 years for patients with RA as the underlying cause and 67.9 years for patients with deaths in which RA was a non-underlying cause.

Comment: no surprise. Patients with Ra need to be monitored closely.


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Marlborough mussels used in fight against arthritis


Can this creature help your arthritis? Next…
Marlborough mussels used in fight against arthritis
ASHLEIGH MONK writing in BusinessDay reported a Marlborough seafood company is helping fight the battle against arthritis with green-lipped mussels.
‘Mussel powder’ is more effective in treating joint pain than glucosamine, according to a study conducted by Queensland University in 2012.
Clearwater Mussels supply mussels to Talley’s Seafood Wholesaler, in Blenheim, who then supply about 20 to 30 tons of green-lipped mussels a day to nutraceutical company MacLab.
Clearwater Mussels owner John Young said the use of the mussels for arthritis treatment was a cause his company to be able to contribute to.
The 2012 Australian study involved treating 38 people who suffered from joint pain and inflammation during a 12-week trial.
The results found the powder “worked faster and provided better relief from pain” than glucosamine, said clinical investigator Samantha Coulson.
Comment: Well… I’ll be ….


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Can depression worsen RA symptoms?



Can your mood affect arthritis symptoms? The answer next…
Can depression worsen RA symptoms?
Dr. Bonnie Bermas writing in the Harvard health blog reported roughly one in six people with rheumatoid arthritis (RA) suffers from depression. Common symptoms of depression, such as fatigue, achiness, and difficulty completing activities of daily life (for example, dressing, cooking, cleaning), can mimic the symptoms of an arthritis flare. It is also possible that depression can contribute to a flare.
A team of researchers studied 379 people with RA who were already enrolled in a trial to compare different medications for the treatment of their arthritis. Participants were asked to describe their feelings using one of the following sentences: “I am not anxious or depressed,” “I am moderately anxious or depressed,” or “I am extremely anxious or depressed.” This assessment was administered alongside standard scales used to measure whether RA symptoms are getting better or worse, or remaining stable (what doctors call disease activity).
The researchers found that the participants reporting more anxiety and depression had higher disease activity scores. They also reported more tender joints and, when asked about their symptoms, they themselves rated their disease activity as higher. At the same time, depression and anxiety seemed to have no effect on the number of swollen joints found during physical exams or the level of inflammation in the body as measured by a blood test called ESR (also known as the sedimentation rate).
Comment: You were expecting something different?


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Knee Pain Felt More By Women


So… which gender experiences more pain due to knee osteoarthritis? The answer will surprise you…next

 Women experience greater pain sensitivity with knee osteoarthritis

Mohan Garikiparithi writing for Health News reported knee osteoarthritis can make daily tasks, such as walking and climbing stairs, quite difficult. However, a new study has revealed that when it comes to the pain associated with knee osteoarthritis, women have a greater sensitivity than men.

Researchers found that women have a lower tolerance for heat, cold and pressure in comparison to men. The findings may be beneficial for doctors and help them determine appropriate treatment for men versus women. Furthermore, additional research may help create new, sex-specific treatments that will be more effective for men and women alike.

Lead author, Dr. Emily Bartley, said, “Many questions still remain as to why women with knee osteoarthritis are more sensitive to painful stimuli than are men. While therapeutic approaches to control pain are only beginning to take these sex differences into account, there is still quite a bit of research yet to be done to help reduce this gender gap and improve clinical therapies for men and women alike.”

The findings were published in Arthritis Care and Research.

Comment: Bet you weren’t expecting that


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How toxic is methotrexate to the liver


How toxic is methotrexate to the liver

Methotrexate increases risk of liver abnormalities but not serious liver damage

Amy Karon writing in Rheumatology News reported that methotrexate use doubled the risk of liver enzyme abnormalities but was not ties to serious outcomes in patients with rheumatic disease, according to a meta-analysis of 32 randomized controlled trials. The study examined more than 13 thousand patients and was published in Seminars in Arthritis and Rheumatism.

Comment: methotrexate is our workhorse drug for many rheumatic conditions. It’s comforting to know that the liver toxicity profile is not serious.


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Smokers with low back pain must quit to feel better


If you have low back pain and smoke, listen up…

Smokers with low back pain must quit to feel better

Deepak Chitnis writing in Rheumatology News reported that according to a study presented at the American Academy of pain Management, patients that quit smoking find relief.

Smoking causes pain receptor desensitization creating the perception that a relatively small amount of pain is more severe than it really is. Smoking also leads to structural changes in the spine that can cause pain and smoking also impairs oxygen delivery to areas of healing.

Comment: stop smoking.


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