Browsing Tag: rheumatoid arthritis

Nanoparticles Rheumatoid Arthritis

A novel method for detection and treatment in rheumatoid arthritis… next

Rheumatoid Arthritis Effectively Diagnosed And Treated With Biodegradable Nanoparticles In Early Study

Dr. Patricia Inacio writing in Rheumatoid Arthritis News reported biodegradable polymer nanoparticles (BNPs), tiny particles made of a biodegradable polymer, appear to be quite useful for the early detection and for long-term, effective treatment of rheumatoid arthritis (RA) with minimal side effects, according to a study presented at the recent . These particles, once coated with a molecule that specifically targets inflamed joint tissues, ensure a high degree of efficacy in delivering both diagnostic probes and drugs to arthritic joints.

Dr. Paolo Macor, the study’s lead investigator from the Department of Life Sciences, University of Trieste, Italy said “There is a need to develop a new tool to enable early diagnosis, and also to develop tissue-specific agents able to reduce systemic side effects. This would increase the potency of drugs with lower doses, and also potentially reduce the cost of treatment,” Dr. Macor said.

Comment: Exciting and I look forward to hearting more.

Vagus Nerve Stimulation Helps Rheumatoid Arthritis

Here’s an interesting twist on rheumatoid arthritis treatment… next

Nerve Stimulation ‘Eases Symptoms’ Of Chronic Condition Rheumatoid Arthritis

Olivia Lerche writing in the Express reported scientists believe stimulating the vagus nerve, which controls electrical signals to the stomach, heart and lungs, can significantly reduce pain and swelling caused by chronic joint inflammation.

The nerve can be stimulated with an electrical device surgically implanted into the body to send pulses through the vagus at various intervals.

Clinical trial data published in the Proceedings of the National Academy of Sciences (PNAS) revealed stimulating the vagus nerve with a bioelectronic device significantly improved the level of disease in patients with rheumatoid arthritis (RA).

Comment: Wow. This is unreal … I really am excited about this one.

Anxiety Reduces Response to Methotrexate

One very important determinant of response to methotrexate…

Anxiety Prior To Methotrexate Therapy May Result In Non-Response At 6 Months

Reported in Healio… patients with rheumatoid arthritis who experience anxiety prior to the start of methotrexate therapy may have non-response at 6 months due to poor adherence, according to results presented at the EULAR Annual Congress.

“From a long list of lifestyle, clinical and psychosocial predictors at baseline, BMI, smoking and DAS28 score were each shown to significantly predict non-response 6 months after patients had started treatment with methotrexate,” Suzan Verstappen, of the Centre for Musculoskeletal Research at the University of Manchester, United Kingdom, said in a press release. “Of particular interest, however, is the role of participant anxiety on starting treatment with methotrexate in predicting response, which is likely to be the result of its negative effect on adherence.”

Comment: the mind is a powerful influence

Rheumatoid Arthritis and Gout Diverging

One arthritis disease is leading to more hospitalizations and the other is causing fewer… next

Costs For Gout And Rheumatoid Arthritis

Reported in ET Health World …While hospitalizations related to rheumatoid arthritis have dropped considerably over the past two decades, hospitalizations primarily associated with gout have increased dramatically. These results of a study described in a research letter in JAMA reflect improved management of rheumatoid arthritis patients and both an increased prevalence and persistent suboptimal care of gout.

Comment: I’m not surprised. While getting RA patients into remission is easier, identifying and treating gout patients is getting harder. Much of that could be attributed to the obesity epidemic.

Rheumatoid Arthritis Patients Screen for Hearing Loss

Can you hear me now… maybe not if you have rheumatoid arthritis… next

Screening Rheumatoid Arthritis Patients for Hearing Impairments is Vital

Rachel Lutz writing for MD reported rheumatoid arthritis (RA) patients should be screened for hearing impairments.

Researchers from Odense University Hospital in Denmark TK evaluated published clinical reports related to hearing impairment in patients with RA. Additionally, they aimed to determine possible pathologies and associated factors as well as new treatment modalities for RA patients with auditory deficit.

Patients with RA are at a higher risk for having a hearing impairment compared to healthy subjects over the course of the disease, the researchers extrapolated. The team also reported that the hearing impairment in RA patients appears to be a multifactorial condition, but they were unable to determine the mechanism of the injury and the relative risk factors.  Some of the factors include smoking, alcohol and noise, which can all deteriorate hearing abilities, they said. For RA patients more specifically, long term alcohol exposure could affect hearing loss and impact the cochlear function over time.

Comment: Interesting.

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