Browsing Tag: rheumatoid arthritis

Depression Predicts Reponse in RA


The mind in patients with rheumatoid arthritis is a power thing… next

Depression and Anxiety Predict Treatment Response and Health Outcomes in Rheumatoid Arthritis

Daniela Samedo writing in rheumatoid Arthritis News reported depression and anxiety are highly prevalent RA patients, with a recent meta-analysis reporting a 16.8% prevalence of depression, diagnosed via clinical interview. There is evidence to suggest a downstream relationship between distress and disease outcomes, with depression increasing pain and disease activity and decreasing short- and long-term treatment efficacy in RA.

Findings from a recent study published in the journal Rheumatology revealed that baseline and persistent symptoms of depression/anxiety predict several subjective and objective rheumatological outcome measures.

To examine the impact of symptoms of depression/anxiety on treatment response, long-term disease activity and physical disability in RA, Faith Matcham and colleagues from the Department of Psychological Medicine, Institute of Psychiatry, King’s College London in the United Kingdom and colleagues, performed an analysis of an existing randomized controlled trial in patients with early RA. Results revealed that in a population of 379 patients, early RA baseline depression/anxiety symptoms were associated with increased disease activity.

Comment: No surprise here.

Statins Lower Death in RA

Cholesterol lowering drugs reduce mortality in rheumatoid arthritis? The answer next.

Statins lower mortality in rheumatoid arthritis patients

Amy Karon writing in rheumatology News reported that a study in the Annals of the Rheumatic Diseases showed that there was a 21% reduced risk of dying in rheumatoid arthritis patients who were on statin therapy. The study was conducted in the United Kingdom using a general practice medical database.

Comment: Interesting finding.

Salsalate Dementia


An old arthritis drug for Alzheimer’s next…

Arthritis drug salsalate ‘may help treat Alzheimer’s’

Salsalate was found to inhibit a chemical process called tau acetylation

An “old” drug used to treat rheumatoid arthritis may offer new hope in the fight against Alzheimer’s and other forms of dementia, say scientists.

von Radowitz writing in the Belfast Telegraph reported in laboratory mice the anti-inflammatory drug, salsalate, prevented damage to the brain associated with the diseases and reversed memory loss.

The early research points towards an as-yet untried treatment strategy that could be effective in combating the devastating effects of Alzheimer’s, it is claimed.

One of the hallmarks of dementia is the formation of so-called tau tangles, toxic twisted knots of protein within nerve cells.

Salsalate was found to inhibit a chemical process called tau acetylation that appears to drive tangle generation.

The drug was tested on genetically engineered mice with frontotemporial dementia (FTD), a form of dementia affecting the frontal lobes of the brain. Tau tangles are a feature of both this disease and Alzheimer’s.

Dr Li Gan, from the Gladstone Institute of Neurological Disease in San Francisco, US, who co-led the research, said: “We identified for the first time a pharmacological approach that reverses all aspects of tau toxicity.

Comment: salsalate is an old old drug, a salicylate we used to use for its anti-inflammatory effects. Very Interesting.

Yoga For Arthritis


Is there something other than a pill or shot that will definitely help with arthritis…? Next

Study Says Yoga Can Ease Arthritis, Boost Mood

 

Diane Depra writing for Tech times reported a study has found that yoga is safe and effective as a means of staying active for those with arthritis, given certain adjustments are incorporated into a routine to address individual limitations.

 

A randomized trial has found that yoga is safe and effective for people with rheumatoid arthritis and knee osteoarthritis, two common forms of arthritis.

 

In a study published in The Journal of Rheumatology, researchers report that yoga classes taken for eight weeks have improved not just the physical but the mental well-being as well of people with rheumatoid arthritis and knee osteoarthritis. This isn’t the first time that researchers have explored the benefits of yoga but the study is the biggest randomized trial so far to tackle yoga’s effects on physical and psychological health.

 

Susan Bartlett, one of the authors of the study, said that there is a growing interest in yoga as a form of complementary treatment, with one out of every 10 people in the United States now engaged in the activity to improve their health and fitness. Yoga works for those with arthritis because it brings together physical activity and relaxation and stress management techniques while acknowledging varying limitations.

 

Comment: I have taken yoga for more than 2 years at my wife’s urging. It helps with stretching, balance, strength, and breathing all of which are important for patients with arthritis.

Tapering Biologics with Rheumatoid Arthritis?

Is it a good idea to taper biologic therapy? Find out next.

 

Tapering Biologics with Rheumatoid Arthritis?

 

Two studies described by Mitchell Zoler and Michelle Sullivan in Rheumatology News allegedly demonstrated that patients with RA could taper their biologics while maintaining control of their disease and saving money. The downside is that in one study remission was maintained in only 43% of patients and in the other study, 37% relapsed.

 

My comment: Once a patient has lost their remission, it’s incredibly hard to get it back. I’m not sure I go along with biologic tapering.

 

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