Browsing Tag: ra

Immunosuppresives Do Not Increase Breast Cancer Recurrence


Do the immunosuppressive drugs used in rheumatoid arthritis treatment increase cancer risk?  The answer next…

Most immunosuppressive drugs do not significantly increase the risk of breast cancer recurrence

Dr. Lara Pullen writing in Arthritis and Rheumatology reported on a study involving 3 large populations of women with rheumatoid arthritis or inflammatory bowel disease who had undergone surgery for primary breast cancer. What the researchers found was that the risk of breast cancer recurrence in patients who received methotrexate or anti-TNF therapy did not have a significant risk of breast cancer recurrence.

Comment: I think this is reassuring news for clinicians who choose to start methotrexate or anti-TNF therapy in rheumatoid arthritis or inflammatory bowel disease patients with treated breast cancer.

Nanoparticles Rheumatoid Arthritis


A novel method for detection and treatment in rheumatoid arthritis… next

Rheumatoid Arthritis Effectively Diagnosed And Treated With Biodegradable Nanoparticles In Early Study

Dr. Patricia Inacio writing in Rheumatoid Arthritis News reported biodegradable polymer nanoparticles (BNPs), tiny particles made of a biodegradable polymer, appear to be quite useful for the early detection and for long-term, effective treatment of rheumatoid arthritis (RA) with minimal side effects, according to a study presented at the recent. These particles, once coated with a molecule that specifically targets inflamed joint tissues, ensure a high degree of efficacy in delivering both diagnostic probes and drugs to arthritic joints.

Dr. Paolo Macor, the study’s lead investigator from the Department of Life Sciences, University of Trieste, Italy said “There is a need to develop a new tool to enable early diagnosis, and also to develop tissue-specific agents able to reduce systemic side effects. This would increase the potency of drugs with lower doses, and also potentially reduce the cost of treatment,” Dr. Macor said.

Comment: Exciting and I look forward to hearing more.

Rheumatoid Arthritis Gut


Got guts…next?

Searching for Rheumatoid Arthritis in the Gut

A pair of recent studies look in an interesting place to find commonality among rheumatoid arthritis sufferers:

Their guts.

Ryan Black writing for MD reported on a study published in Genome Medicine from the Mayo clinic. Veena Taneja, Ph D of the Mayo Clinic’s Center for Immunized Medicine said they sought to find a biomarker in the form of gut microbiota. Examining fecal samples of (human) RA patients and their first-degree relatives, the researchers noticed that an abundance of collinsella in the gut was linked to increased RA symptoms.

To test this, they administered collinsella to “humanized” mice, and found that “Mice given [Collinsella aerofaciens] developed arthritis with increased incidence and severity compared with non-treated mice (100 % incidence in treated vs 62.5 % in untreated, P = 0.068).” Their findings indicate that collinsella may be a predictive biomarker for RA in humans.

Comment: Maybe I’ll stay away from pepperoni pizza…

Etanercept Alzheimers


Hope for Alzheimer’s… maybe

Arthritis drug could reduce risk of having Alzheimer’s disease

Nicholas Bakalar writing for Business Standard reported a drug used to treat rheumatoid arthritis may have benefits against Alzheimer’s disease, researchers report.

Rheumatoid arthritis is an autoimmune disease believed to be driven in part by tumour necrosis factor, or TNF, a protein that promotes inflammation. Drugs that block TNF, including an injectable drug called etanercept, have been used to treat rheumatoid arthritis for many years.

TNF is also elevated in the cerebrospinal fluid of Alzheimer’s patients.

Researchers identified 41,109 men and women with a diagnosis of rheumatoid arthritis and 325 with both rheumatoid arthritis and Alzheimer’s disease. In people over 65, the prevalence of Alzheimer’s disease was more than twice as high in people with rheumatoid arthritis, as in those without it. The study is in CNS Drugs.

But unlike patients treated with five other rheumatoid arthritis drugs, those who had been treated with etanercept showed a significantly reduced risk for Alzheimer’s disease.

Comment: Interesting to see what future developments occur.

Nanoparticles Rheumatoid Arthritis


A novel method for detection and treatment in rheumatoid arthritis… next

Rheumatoid Arthritis Effectively Diagnosed And Treated With Biodegradable Nanoparticles In Early Study

Dr. Patricia Inacio writing in Rheumatoid Arthritis News reported biodegradable polymer nanoparticles (BNPs), tiny particles made of a biodegradable polymer, appear to be quite useful for the early detection and for long-term, effective treatment of rheumatoid arthritis (RA) with minimal side effects, according to a study presented at the recent . These particles, once coated with a molecule that specifically targets inflamed joint tissues, ensure a high degree of efficacy in delivering both diagnostic probes and drugs to arthritic joints.

Dr. Paolo Macor, the study’s lead investigator from the Department of Life Sciences, University of Trieste, Italy said “There is a need to develop a new tool to enable early diagnosis, and also to develop tissue-specific agents able to reduce systemic side effects. This would increase the potency of drugs with lower doses, and also potentially reduce the cost of treatment,” Dr. Macor said.

Comment: Exciting and I look forward to hearting more.

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