Another Treatment Modality For Rheumatoid Arthritis… Next
Pedometers increase activity and decrease fatigue in rheumatoid arthritis patients
Wiley writing for Eureka Alert reported providing pedometers, with and without providing step targets, to individuals with rheumatoid arthritis increased activity levels and decreased fatigue in a recent study.
In control patients who did not receive pedometers, average daily steps declined and there was no significant change in fatigue.The findings are important because fatigue can have a significant impact on quality of life for individuals with rheumatoid arthritis, but effective and feasible treatments are limited.
“Because rheumatoid arthritis medications have only small effects on fatigue, it’s important for patients to have other ways to manage their fatigue,” said Dr. Patricia Katz, lead author of the Arthritis Care & Research study. “These results suggest that something as simple as increasing physical activity by walking can help.”
One simple task you can do to prevent rheumatoid arthritis
Brush And Floss To Prevent Rheumatoid Arthritis
Ruth Kava writing for the American council on Science and Health reported recent research published in Science Translational Medicine suggests how good dental care might well be an important factor in preventing the onset of RA.
The investigators, led by Dr. Maximilian Koenig from the Johns Hopkins University School of Medicine, explained that a bacterium associated with periodontal disease — Aggregatibacter actinomycetemcomitans (Aa) — could be the initiator of the autoimmune feature of RA. The investigators noted that Aa, of all the other identified microbes, was the only one known that could produce the spectrum of antigens found in the joints of individuals with RA.
To investigate this possibility, they collected fluid from the gum regions of people with periodontal disease and from those of controls and analyzed them for the presence of altered proteins which are known to be immune system targets. In sum, people with periodontitis are more likely to have the Aa bacterial toxin and thus more likely to produce targets for the immune system. This in turn, links periodontal disease and rheumatoid arthritis.
Comment: An interesting finding that confirms the research of others.
Reported in Unavadis, a large study of Swedish health registry data indicates that lymphoma risk remains elevated among patients with rheumatoid arthritis (RA), despite evolution of treatment. Treatment advances for RA do not appear to have affected lymphoma risk. Records from 12,656 patients with RA from the Swedish Rheumatology Register linked to Swedish Cancer Register were compared with control patients for lymphoma incidence over time.
Comment: Disturbing since I would expect our newer treatments to decrease lymphoma risk.
Study Shows Potential for Early Diagnosis of Arthritis
Pat Anson writing for Pain News Network reported a new study by British researchers has demonstrated the potential for an experimental blood test that can diagnose arthritis in its earliest stages. Such a test could lead to earlier treatment of osteoarthritis (OA) and rheumatoid arthritis (RA), years before joint damage and physical symptoms begin.
Researchers at Warwick Medical School recruited 225 people with early or advanced OA, RA or another inflammatory joint disease, along with a control group of healthy volunteers with no joint problems. Their blood and fluid from affected knee joints were then analyzed with mass spectrometry.
The test found patterns in blood plasma amino acids that were damaged by oxygen, nitrogen and sugar molecules. The damage was highest in the blood samples of patients with OA or RA, and markedly lower in the blood of healthy volunteers — giving researchers identifiable biomarkers that could be used for an early diagnosis.
“This is a big step forward for early-stage detection of arthritis that will help start treatment early and prevent painful and debilitating disease,” said Naila Rabbani, PhD, of Warwick Medical School. “Damage to proteins in the arthritic joint have been known for many years but this is the first time it has been exploited for early-stage diagnosis.
“For the first time we measured small fragments from damaged proteins that leak from the joint into blood. The combination of changes in oxidised, nitrated and sugar-modified amino acids in blood enabled early stage detection and classification of arthritis – osteoarthritis, rheumatoid arthritis or other self-resolving inflammatory joint disease.”
Do the immunosuppressive drugs used in rheumatoid arthritis treatment increase cancer risk? The answer next…
Most immunosuppressive drugs do not significantly increase the risk of breast cancer recurrence
Dr. Lara Pullen writing in Arthritis and Rheumatology reported on a study involving 3 large populations of women with rheumatoid arthritis or inflammatory bowel disease who had undergone surgery for primary breast cancer. What the researchers found was that the risk of breast cancer recurrence in patients who received methotrexate or anti-TNF therapy did not have a significant risk of breast cancer recurrence.
Comment: I think this is reassuring news for clinicians who choose to start methotrexate or anti-TNF therapy in rheumatoid arthritis or inflammatory bowel disease patients with treated breast cancer.