Browsing Tag: oa

Steroid Injections May Be No Better Than Placebo For Pain Linked To Knee Osteoarthritis

Steroid Injections May Be No Better Than Placebo For Pain Linked To Knee Osteoarthritis, Study Suggests

Nicholas Bakalar writing for the New York Times reported that while physicians “often prescribe steroid injections for the pain of knee arthritis,” research published in the Journal of the American Medical Association “has found they work no better than a placebo.”

Randy Dotinga writing for Healthday added that investigators found that individuals with knee osteoarthritis who received “steroid injections every three months for two years had no less pain than those taking a placebo treatment.” Additionally, researchers found that “they had greater loss of cartilage.”

Comment: What a bunch of horse doo-doo. These injections do work and this study is an example of stupidity.

Noisy Knees Early Sign of Osteoarthritis


An early sign of osteoarthritis in the knees… next

Noisy Knees Could Signal Onset Osteoarthritis Research Finds.

Diane King writing in the Edinburgh News reported noisy knees may be an early sign of osteoarthritis, new research suggests. People who hear grating, cracking or popping sounds in and around their knee joints are more likely to develop the condition, say scientists. Researchers conducted a multi-centre observational study that included almost 3,500 participants at high risk of knee osteoarthritis. The chances of them developing pain symptoms over a period of up to four years increased with greater frequency of knee noise. It doubled when the noises were heard “often” and trebled for patients who said they “always” experienced them. The findings, published in the journal Arthritis Care & Research, may lead to new ways of diagnosing and treating osteoarthritis earlier, said the researchers. US lead author Dr Grace Lo, from Baylor College of Medicine in Houston, Texas, said: “Many people who have signs of osteoarthritis on X-rays do not necessarily complain of pain, and there are no known strategies for preventing the development of pain in this group of people. “This study suggests that if these people have noisy knees, they are at higher risk for developing pain within the next year compared with the people who do not have noisy knees.

Comment: Noisy knees are pretty common and so is osteoarthritis of the knees.

Silk Delivery for Arthritis


Tired of taking bunches of pills for arthritis?  Here’s an alternative… next

Better than a pill: Team to develop new arthritis treatment via silk

Erika Ebsworth-Goold writing in Medical Xpress reported a team of researchers from Washington University in St. Louis will use silk micro-particles to deliver long-lasting therapeutic compounds, helping better alleviate the pain of inflammation and injury.

“We’re starting to see that many areas can’t be reached via oral drug delivery,” said Lori Setton, the Lucy & Stanley Lopata Distinguished Professor of Biomedical Engineering at the School of Engineering & Applied Science.

Setton, said an intracellular compound called nuclear factor kappa B (NF-kB) is a main culprit in cellular breakdown, inflammation and pain after an injury. She’s working in the lab on a new solution using silk to deliver two specific molecules that can inhibit NF-kB at the site of a fracture or injury in an effort to stave off long-term joint damage.

“Silk naturally doesn’t interact with water, and, when you mix it with these molecules that also don’t interact with water, they bind to each other very strongly,” Setton said. “We believe these selective compounds are therapeutically effective, but we’ve never been able to get them to their target site. By delivering them with the silk, we hope to get large doses to the target site with low toxicity and to have them remain in that compartment for longer periods of time.”

Silk is an attractive delivery vehicle because of its long history of safe clinical use

According to Setton, the enhanced drug-delivery system has the potential to prevent the onset and progression of joint damage in patients suffering from acute injuries, like minor joint fractures, ligament or meniscal tears.

“Patients with joint trauma tend to go on to develop osteoarthritis at a higher rate compared to someone who doesn’t have the injury,” Setton said. “It’s a whole different type of arthritis development that we don’t know a whole lot about, but we believe we can intervene early with new drug delivery and treatments, and prevent onset at a later stage.”

Comment: Nice concept

Reduced Risk of Death in Weekend Warriors


Hey… are you a weekend warrior?   Here’s some good news for you…

Do Exercise ‘Weekend Warriors’ Lower Their Risk Of Death?

Dr. Jack cush writing in RheumNow reported a new article published in JAMA Internal Medicine suggests that compared with inactive adults, weekend warriors who performed the recommended amount of 150 minutes of moderate or 75 minutes of vigorous activity in one or two sessions per week had lower risks for death from all causes, cardiovascular disease (CVD) and cancer.

Although it may be easier to fit less frequent bouts of activity into a busy lifestyle, little has been known about the weekend warrior physical activity pattern.

Gary O’Donovan, Ph.D., of Loughborough University, England, and coauthors conducted a pooled analysis of 63,591 adults who responded to English and Scottish household-based surveys. Data were collected from 1994 to 2012. The authors looked at associations between the weekend warrior and other physical activity patterns and the risk for death from all causes, CVD and cancer.

The risk of death from all causes was about 30 percent lower among weekend warrior adults compared with inactive adults, while the risk of CVD death for weekend warriors was 40 percent lower and the risk of cancer death was 18 percent lower.

Comment: Wow.  Unexpected good news.

Effectiveness of PRP for OA of the Knee


Which works better for osteoarthritis of the knee?  Find out next…

Efficacy Of Platelet-Rich Plasma In The Treatment Of Knee Osteoarthritis: A Meta-Analysis Of Randomized Controlled Trials.

Dr. Jack Cush writing in Rheumnow reported on a large study evaluating the use of platelet rich plasma (PRP) vs other therapies. The analysis showed that at 6 months postinjection, PRP and hyaluronic acid (HA) had similar effects with respect to pain relief.   At 12 months postinjection, however, PRP was associated with significantly better pain relief than HA. The researchers also noted that PRP did not increase the risk of adverse events compared with HA and saline.

Current evidence indicates that, compared with HA, intra-articular PRP injection may have more benefit in pain relief and functional improvement in patients with symptomatic knee OA at 1 year postinjection.

Comment: PRP is definitely an effective treatment modality for OIA of the knee. It must be administered via US though for best results.

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