Tired of taking bunches of pills for arthritis? Here’s an alternative… next
Better than a pill: Team to develop new arthritis treatment via silk
Erika Ebsworth-Goold writing in Medical Xpress reported a team of researchers from Washington University in St. Louis will use silk micro-particles to deliver long-lasting therapeutic compounds, helping better alleviate the pain of inflammation and injury.
“We’re starting to see that many areas can’t be reached via oral drug delivery,” said Lori Setton, the Lucy & Stanley Lopata Distinguished Professor of Biomedical Engineering at the School of Engineering & Applied Science.
Setton, said an intracellular compound called nuclear factor kappa B (NF-kB) is a main culprit in cellular breakdown, inflammation and pain after an injury. She’s working in the lab on a new solution using silk to deliver two specific molecules that can inhibit NF-kB at the site of a fracture or injury in an effort to stave off long-term joint damage.
“Silk naturally doesn’t interact with water, and, when you mix it with these molecules that also don’t interact with water, they bind to each other very strongly,” Setton said. “We believe these selective compounds are therapeutically effective, but we’ve never been able to get them to their target site. By delivering them with the silk, we hope to get large doses to the target site with low toxicity and to have them remain in that compartment for longer periods of time.”
Silk is an attractive delivery vehicle because of its long history of safe clinical use
According to Setton, the enhanced drug-delivery system has the potential to prevent the onset and progression of joint damage in patients suffering from acute injuries, like minor joint fractures, ligament or meniscal tears.
“Patients with joint trauma tend to go on to develop osteoarthritis at a higher rate compared to someone who doesn’t have the injury,” Setton said. “It’s a whole different type of arthritis development that we don’t know a whole lot about, but we believe we can intervene early with new drug delivery and treatments, and prevent onset at a later stage.”
Hey… are you a weekend warrior? Here’s some good news for you…
Do Exercise ‘Weekend Warriors’ Lower Their Risk Of Death?
Dr. Jack cush writing in RheumNow reported a new article published in JAMA Internal Medicine suggests that compared with inactive adults, weekend warriors who performed the recommended amount of 150 minutes of moderate or 75 minutes of vigorous activity in one or two sessions per week had lower risks for death from all causes, cardiovascular disease (CVD) and cancer.
Although it may be easier to fit less frequent bouts of activity into a busy lifestyle, little has been known about the weekend warrior physical activity pattern.
Gary O’Donovan, Ph.D., of Loughborough University, England, and coauthors conducted a pooled analysis of 63,591 adults who responded to English and Scottish household-based surveys. Data were collected from 1994 to 2012. The authors looked at associations between the weekend warrior and other physical activity patterns and the risk for death from all causes, CVD and cancer.
The risk of death from all causes was about 30 percent lower among weekend warrior adults compared with inactive adults, while the risk of CVD death for weekend warriors was 40 percent lower and the risk of cancer death was 18 percent lower.
Which works better for osteoarthritis of the knee? Find out next…
Efficacy Of Platelet-Rich Plasma In The Treatment Of Knee Osteoarthritis: A Meta-Analysis Of Randomized Controlled Trials.
Dr. Jack Cush writing in Rheumnow reported on a large study evaluating the use of platelet rich plasma (PRP) vs other therapies. The analysis showed that at 6 months postinjection, PRP and hyaluronic acid (HA) had similar effects with respect to pain relief. At 12 months postinjection, however, PRP was associated with significantly better pain relief than HA. The researchers also noted that PRP did not increase the risk of adverse events compared with HA and saline.
Current evidence indicates that, compared with HA, intra-articular PRP injection may have more benefit in pain relief and functional improvement in patients with symptomatic knee OA at 1 year postinjection.
Comment: PRP is definitely an effective treatment modality for OIA of the knee. It must be administered via US though for best results.
How much weight does wearing a fitness tracker help you lose? Next
Wearable Activity Trackers Don’t Improve Weight Loss
Dr. Jack Cush writing in Rheum now reported that an article in JAMA has reported the results of a 24-month trial showing that obese individuals on a long-term healthy diet and exercise program do not have significantly more weight loss from using a wearable device that tracks their activity.
In a randomized clinical trial conducted at the University of Pittsburgh, 471 adult participants (with a BMI between 25-40) enrolled between 2010 and 2012. All subjects were placed on a low-calorie diet, prescribed increases in physical activity, and had group counseling sessions.
Patients randomized to the intervention group were given wearable device and accompanying web interface to monitor diet and physical activity – BodyMedia Fit Core, a wearable activity tracker worn on the upper arm. The Fit Core tracks steps, hours slept and calories burned and costs about $100.
After 24 months, people who used wearable activity trackers lost 2.4 kilograms (5.29 pounds) less than a group on a similar program but using a website to track their progress.
Both groups had improved their body composition, fitness, physical activity and diet, according to the report in JAMA.
The value and impact of wearable technology remains to be proven, especially with regard to weight loss.