Sara Freeman writing in Rheumatology news reported on a study that showed that persistent knee pain is in important predictor of structural joint damage and could potentially be used to predict knee osteoarthritis earlier according to Dutch research reported at the World Congress on Osteoarthritis. The analysis found that women participating in the Rotterdam study who had knee pain on most days of the preceding month were more than 4 times more likely to develop knee osteoarthritis within 5 years on MRI than were those without frequent knee pain.
Bruce Jancin writing in rheumatology News reported on a British study of more than 13,000 patients who underwent total knee replacement. A matched nonsurgical group was used as control. During the first month after knee replacement, there was an almost 9 fold increase in the risk of heart attack compared with the control group. At 3 months the risk was four times greater and at 6 months 2 times greater. Another finding was that the risk of venous thromboembolism- a blood clot that goes to the lungs- remained elevated for 5 years.
Comment: Wow… not good news for you if you want to have a knee replaced.
What’s the best drug for delaying knee replacement… next
Study finds best anti-inflammatory for delaying knee osteoarthritis’ progression
Michael Johnsen writing for Drug Store News reported chondroitin sulfate is superior to an anti-inflammatory drug, celecoxib, for delaying the progression of knee osteoarthritis, according to a new study presented by Jean-Pierre Pelletier, from the University of Montreal (Canada), at the official press conference of the Annual meeting of the American College of Rheumatology.
The study, named MOSAIC, was a multicenter, randomized, double blind, controlled and comparative study analyzing chondroitin sulfate and celecoxib. The study recruited 194 patients suffering from knee osteoarthritis with inflammation and moderate pain. Participants were divided into two groups: the first group received 1,200 mg of pharmaceutical grade chondroitin sulfate (made by Bioiberica) per day, while the second group received 200 mg of celecoxib per day, over a two-year period. The participants underwent three Quantitative Magnetic Resonance scans: one at the beginning of the study, a second one after one year, and a third one at the end of the study.
The results revealed that the progression of knee osteoarthritis is slower in patients receiving chondroitin sulfate. More precisely, this group experienced a statistically significant lower loss of cartilage volume after the first year of treatment, in comparison with those patients who received the anti inflammatory drug. “This data proves that chondroitin sulfate may delay the advance of osteoarthritis in the long term, and that it had a disease-modifying effect,” affirmed Pelletier.
The study also evaluated the effects of both drugs on pain, function, stiffness, joint efflux and swelling; concluding that both treatments were equally efficient across the entire study, reaching a clinically relevant symptom improvement of around 50%.
“The study confirmed that both drugs are efficient for the treatment of osteoarthritis symptoms, although only chondroitin sulfate has the additional advantage of exerting a joint protection effect and a better safety profile,” Pelletier said.
Comment: a neutriceutical that outperforms a pharmaceutical. Wow!!
A very promising method for regenerating cartilage…
Reported in CMI (Healthcare Medicine Institute), acupuncture combined with herbs is effective for the relief of knee osteoarthritis pain. Shanghai University of Traditional Chinese Medicine (TCM) researchers conducted a controlled trial and concluded that acupuncture with herbs is both safe and effective. No harmful side effects resulted from the treatment regimen and patients demonstrated significant improvements. The researchers document significant reductions in knee pain with concomitant joint function improvement.
The researchers conducted a highly controlled experiment wherein acupuncture point prescriptions were standardized to a set of specific acupuncture points with predetermined manual acupuncture stimulation procedures. Two acupuncture protocols were compared between treatment groups. One group received acupuncture with herbs in what was termed the Shi treatment procedure. The other protocol of care employed only a standard set of acupuncture points without the use of herbal medicine.
The Shi acupuncture with herbs technique outperformed the acupuncture only group.
Comment: While the effectiveness of acupuncture in treating osteoarthritis remains controversial, more and more studies support its use since the side effect profile is so low.
Can pinning joints work for knee osteoarthritis? Next
Joint distraction may prevent need for knee replacement in patients with knee OA
Sara Freeman writing for rheumatology news reported that joint distraction which involves temporarily pinning the knee to relieve mechanical stress may help patients void the need for knee replacement. The study, conducted at the University Medical Center Utrecht and Sint Maartenskliniek in Woerden in the Netherlands showed this procedure may be extremely valuable, particularly in younger individuals.
My comment: Unloading the joint is crucial to slowing down the progression of osteoarthritis of the knee.