Browsing Tag: Hyaluronic Acid

Effectiveness of PRP for OA of the Knee

Which works better for osteoarthritis of the knee?  Find out next…

Efficacy Of Platelet-Rich Plasma In The Treatment Of Knee Osteoarthritis: A Meta-Analysis Of Randomized Controlled Trials.

Dr. Jack Cush writing in Rheumnow reported on a large study evaluating the use of platelet rich plasma (PRP) vs other therapies. The analysis showed that at 6 months postinjection, PRP and hyaluronic acid (HA) had similar effects with respect to pain relief.   At 12 months postinjection, however, PRP was associated with significantly better pain relief than HA. The researchers also noted that PRP did not increase the risk of adverse events compared with HA and saline.

Current evidence indicates that, compared with HA, intra-articular PRP injection may have more benefit in pain relief and functional improvement in patients with symptomatic knee OA at 1 year postinjection.

Comment: PRP is definitely an effective treatment modality for OIA of the knee. It must be administered via US though for best results.

Best Conservative Treatment For Knee OA

So… what’s the best current conservative treatment for knee osteoarthritis? The answer next!

Hyaluronic Acid, Corticosteroids May Be Most Effective Treatment For Pain Of Knee OA.

Nicholas Bakalar writing in the New York Times reported that research published in the Annals of Internal Medicine suggests that “the most effective treatment for the pain of knee osteoarthritis may be an injection of hyaluronic acid or corticosteroids, and the least effective may be” acetaminophen or celecoxib. Investigators came to this conclusion after reviewing “137 randomized trials involving more than 33,000 patients.

Comment: For pain relief this treatment works pretty well. The problem is we still haven’t come up with a treatment for restoring cartilage growth. The exception is mesenchymal stem cells which has been shown to do that.

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