Browsing Tag: depression

Depression in Medical Students

Depression… it’s already starting in young doctors

Many Medical Students Appear To Struggle With Depression, Research Reveals

Liz Kowalczyk writing in the Boston Globe reported that future physicians appear to “suffer depression, or depressive symptoms, at higher rates than the general population,” a meta-analysis involving “nearly 200 smaller studies from 47 countries” suggests.  In fact, about “27 percent” of medical students appear to suffer from “depression in medical school,” the research revealed.  The findings were published in the Journal of the American Medication Association.

Comment: I have news for these students… medical practice today can be even more depressing.

Anti-Cytokines For Depression

A novel treatment for depression… next

Anti-cytokines reduce depression symptoms in clinical trials

Honor Whiteman writing in MNT reported researchers conducted a meta-analysis of 20 clinical trials that assessed the effects of anti-cytokine monoclonal antibodies and cytokine inhibitors in more than 5,000 patients with autoimmune diseases. These are biologic drugs commonly used to treat diseases such as rheumatoid arthritis.

On investigating the additional benefits of the anti-cytokine medications in each trial – seven of which were randomized controlled trials involving a placebo – the team found that the drugs led to a significant reduction in symptoms of depression among participants, regardless of whether they were effective against autoimmune diseases.

While further studies are required, the researchers say their results suggest anti-cytokine medications may be a feasible treatment option for patients with depression – particularly for those who do not respond to current antidepressants.

“About a third of patients who are resistant to antidepressants show evidence of inflammation,” notes Dr. Golam Khandaker, of the Department of Psychiatry at the University of Cambridge in the United Kingdom. “So, anti-inflammatory treatments could be relevant for a large number of people who suffer from depression.”

Comment: Another set of drugs crosses over to a new discipline.


Depression Predicts Reponse in RA

The mind in patients with rheumatoid arthritis is a power thing… next

Depression and Anxiety Predict Treatment Response and Health Outcomes in Rheumatoid Arthritis

Daniela Samedo writing in rheumatoid Arthritis News reported depression and anxiety are highly prevalent RA patients, with a recent meta-analysis reporting a 16.8% prevalence of depression, diagnosed via clinical interview. There is evidence to suggest a downstream relationship between distress and disease outcomes, with depression increasing pain and disease activity and decreasing short- and long-term treatment efficacy in RA.

Findings from a recent study published in the journal Rheumatology revealed that baseline and persistent symptoms of depression/anxiety predict several subjective and objective rheumatological outcome measures.

To examine the impact of symptoms of depression/anxiety on treatment response, long-term disease activity and physical disability in RA, Faith Matcham and colleagues from the Department of Psychological Medicine, Institute of Psychiatry, King’s College London in the United Kingdom and colleagues, performed an analysis of an existing randomized controlled trial in patients with early RA. Results revealed that in a population of 379 patients, early RA baseline depression/anxiety symptoms were associated with increased disease activity.

Comment: No surprise here.

Anxiety and depression common with arthritis

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Anxiety and depression common with arthritis

One-third of U.S residents 45 and older with arthritis have anxiety or depression, a study from the Center for Disease Control and Prevention finds.  According to findings that appear in Arthritis
Care & Research,
anxiety is nearly twice as common as depression among people with arthritis, despite more clinical focus on the latter mental health condition.


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