Browsing Tag: arthritis treatment

Heart Attack After Total Knee Replacement

Disturbing risk of knee replacement… next

Heart Attack After Total Knee Replacement

Bruce Jancin writing in rheumatology News reported on a British study of more than 13,000 patients who underwent total knee replacement. A matched nonsurgical group was used as control. During the first month after knee replacement, there was an almost 9 fold increase in the risk of heart attack compared with the control group. At 3 months the risk was four times greater and at 6 months 2 times greater. Another finding was that the risk of venous thromboembolism- a blood clot that goes to the lungs- remained elevated for 5 years.

Comment: Wow… not good news for you if you want to have a knee replaced.

Tequila Osteoporosis Treatment

Good news for tequila drinker next…

Tequila Could Be the Basis for a New Osteoporosis Treatment

Caitlyn Fitzpatrick writing in MD reported in addition to being the most important ingredient in margaritas, substances derived from tequila can play an important role in health.

Not only did new research find that Agave tequilana (or tequila agave) may help maintain bone health, but it could also be the basis for a new osteoporosis treatment. Mercedes López, PhD, led the project at the Center for Research and Advanced Studies (Cinvestav) in Mexico.

Using animal models, the researchers induced osteoporosis in mice by removing their ovaries. The animals were then given agave fructans (polymers that store carbohydrates in some fruits and vegetables). After eight weeks, femur samples were collected in order to assess the absorption of minerals and osteocalcin (a protein that indicates new bone production).

“It was found that mice that consumed this fructans synthesized nearly 50% more of such protein, in addition that the diameter of their bones was higher compared with the subjects which were not supplied with derivatives of the agave,” López explained.

Comment: It’s getting closer to Cinqo de Mayo.

Osteoporosis Drug Worsens Rheumatoid Arthritis

New osteoporosis drugs work well but may worsen rheumatoid arthritis…

Anti-sclerostin osteoporosis drugs worsen RA

Jeff Evans writing in Rheumatology news reported antisclerostin antibodies increase bone mineral density and have done well in clinical trials in osteoporosis. However, they may have the opposite effect in rheumatoid arthritis according to a German study.  Researchers showed these drugs accelerate joint damage in mouse models of rheumatoid arthritis.

Comment: Often, new drugs aimed at helping one condition can worsen another.

Microbiome Draws Interest

Changing your gut bugs may be the next step in the future of medicine…

Pharmaceutical companies considering potential of treating microbiome

Elizabeth Preston writing in STAT reported that “as scientists learn more about the microbiome’s role in conditions ranging from allergies to anxiety to cancer,” pharmaceutical companies are “paying close attention.” The goal of such research is to “treat or prevent some of our most intractable diseases” by “delivering drugs to the microbiome.”

The microbiome has generated a ton of interest in researchers across all disciplines. It will be interesting to see what happens over the next few years.

Acetaminophen Doesn’t Work for Osteoarthritis Pain

A widely used useless treatment for osteoarthritis. Are you taking it?

Acetaminophen may have little effect on osteoarthritic pain

Melissa Healey writing for the Los Angeles times reported that investigators analyzed data from 74 trials of pain medications. The data, published in the Lancet, indicated that “in older patients with osteoarthritis, acetaminophen provides no more pain relief and improvement in day-to-day function than does a placebo.” The researchers also found that several non-steroidal anti-inflammatory drugs (NSAIDs) had high probabilities of improving arthritis pain of the hips and knees.

Comment: No surprise here.

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