Protein Found In Human Umbilical Cord Blood May Improve Learning And Memory In Older Mice, Study Suggests
In “To Your Health,” Lenny Bernstein writing for the Washington Post reported an infusion of human umbilical cord blood improved the functioning of the hippocampus in mice, according to a study published in Nature. The researchers found that the protein TIMP2 was responsible for the improvements in memory and cognition.
Comment: Human blood improved cognition in mice. I wonder what mouse umbilical cord blood would do for humans?
Diabetes May Be Responsible For More US Deaths Than Previously Believed
Arlene Karidis writing for the Washington Post reported, “Nearly four times as many Americans may die of diabetes as indicated on death certificates, a rate that would bump the disease up from the seventh-leading cause of death to No. 3, according to estimates in a study” published in PLOS One. The study’s lead author said, “We argue diabetes is responsible for 12 percent of deaths in the US, rather than 3.3 percent that death certificates indicate.” The Post added that last year, “diabetes accounted for about $1.04 billion in National Institutes of Health funding, compared with about $5.65 billion spent on cancer research.”
Comment: And I expect it will become even more of a problem in the future.
Cristina Silva reporting for Newsweek stated that the National Institutes of Health’s Annual Report to the Nation on the Status of Cancer indicated “death rates for the most common types of cancer dropped for men, women and children from all racial and ethnic backgrounds from 2010-2014.” Investigators found that “the rates of new cancers were lower for men but held steady for women.”
Comment: As newer therapies are developed, we are slowly beating back this old enemy.
A commonly used drug for sciatica… does it really work? Next
Pregabalin May Be No Better Than Placebo For Relieving The Leg Pain Associated With Sciatica, Study Suggests
Jia Naqvi writing in the Washington Post reported that research suggests pregabalin, which is “frequently prescribed for pain, is no more effective than a placebo at controlling sciatica.” The researchers at the George Institute for Global Health in Australia followed 209 sciatica patients in Sydney who were randomly assigned to receive either the drug pregabalin, more commonly known as Lyrica, or a placebo. The results showed no significant differences in leg pain intensity between the group on the placebo and that on Lyrica after eight weeks taking the drug or during the rest of the year on follow-up exams. Similarly, there were no differences for other outcomes such as back pain, quality of life and degree of disability.The findings were published in the New England Journal of Medicine.
Beta blocker use associated with less joint pain and opioid use in osteoarthritis
Ajai Raj writing in Pain Medicine News reported on a study published in Arthritis Care and Research. A University of Nottingham trial looked at 873 patients with osteoarthritis of the hip or knee. From their prospective observational study they concluded that beta blockers, drugs used commonly for patients with cardiac disease and hypertension helped reduce arthritis related pain. In addition the use of opioids was also reduced. They proposed a randomized trial would better assess these findings.