Hey… are you a weekend warrior? Here’s some good news for you…
Do Exercise ‘Weekend Warriors’ Lower Their Risk Of Death?
Dr. Jack cush writing in RheumNow reported a new article published in JAMA Internal Medicine suggests that compared with inactive adults, weekend warriors who performed the recommended amount of 150 minutes of moderate or 75 minutes of vigorous activity in one or two sessions per week had lower risks for death from all causes, cardiovascular disease (CVD) and cancer.
Although it may be easier to fit less frequent bouts of activity into a busy lifestyle, little has been known about the weekend warrior physical activity pattern.
Gary O’Donovan, Ph.D., of Loughborough University, England, and coauthors conducted a pooled analysis of 63,591 adults who responded to English and Scottish household-based surveys. Data were collected from 1994 to 2012. The authors looked at associations between the weekend warrior and other physical activity patterns and the risk for death from all causes, CVD and cancer.
The risk of death from all causes was about 30 percent lower among weekend warrior adults compared with inactive adults, while the risk of CVD death for weekend warriors was 40 percent lower and the risk of cancer death was 18 percent lower.
Which works better for osteoarthritis of the knee? Find out next…
Efficacy Of Platelet-Rich Plasma In The Treatment Of Knee Osteoarthritis: A Meta-Analysis Of Randomized Controlled Trials.
Dr. Jack Cush writing in Rheumnow reported on a large study evaluating the use of platelet rich plasma (PRP) vs other therapies. The analysis showed that at 6 months postinjection, PRP and hyaluronic acid (HA) had similar effects with respect to pain relief. At 12 months postinjection, however, PRP was associated with significantly better pain relief than HA. The researchers also noted that PRP did not increase the risk of adverse events compared with HA and saline.
Current evidence indicates that, compared with HA, intra-articular PRP injection may have more benefit in pain relief and functional improvement in patients with symptomatic knee OA at 1 year postinjection.
Comment: PRP is definitely an effective treatment modality for OIA of the knee. It must be administered via US though for best results.
Dr. Jack Cush writing in Rheum Now reviewed the safety of proton pump inhibitors, drugs that have been used for peptic ulcer disease, as well as reflux.
Among the safety concerns are…
PPIs will decrease gastric acid and may affect drug blood levels where absorption is acid dependent, including several antiretroviral and cancer therapy drugs. Other drugs, such as digoxin, may be absorbed more extensively when gastric acid is reduced; thus, digoxin toxicity may occur with PPI use. Warfarin’s effect also is increased in patients taking PPIs. Decreased gastric acid can lower absorption of vitamin B12, calcium, iron, and magnesium.
An analysis of 9 studies found a 40% increased risk of low magnesium with PPI. If severe, hypomagnesemia may lead to muscle weakness, tetany, convulsions, arrhythmias.
Due to the lowering of gastric acidity, there is a higher risk of Clostridium difficile infection and community-acquired pneumonia among PPI users.
Recent large reviews show that there is a 50% increased risk of chronic kidney disease and an increased risk of acute kidney disease with chronic PPI use.
PPIs may decrease bone density and increase fracture risk by reducing intestinal calcium absorption.
Given these impactful risks, clinicians should try to use the lowest possible dose of PPI and to discontinue PPI therapy if it is not essential. The benefits of PPI therapy must be weighed against their potential contribution to harm in susceptible individuals. Some patients may benefit from intermittent or on-demand regimens may be sufficient to manage problems or control symptoms.
Elderly women are three times more likely to fracture hip than male peers, study suggests
Shereen Lehman writing for Reuters reported elderly women are three times more likely to fracture a hip than their male counterparts, according to a study conducted by Spanish researchers that was published in Maturitas. The researchers found that depression and illiteracy increased the risk of fracture for elderly women, while disability and smoking increased the risk of fracture for elderly men. The article mentions the “National Institutes of Health warns that being underweight is a risk factor for poor bone health.”
Comment: There are multiple risk factors for women to consider and know about.
Fish Oil Use During Pregnancy Linked To Lower Asthma Risk In Kids
Denise Grady writing for the New York Times reported that research indicated “women who took fish oil during the last three months of pregnancy significantly” reduced the likelihood “that their children would develop asthma.” The findings were published in The New England Journal of Medicine.
Comment: dietary fish oil has multiple benefits and this is another one.