T’ai chi Patient Knee OA

How does Tai chi compare with physical therapy for treating knee osteoarthritis? Next

Tai chi equivalent to Physical therapy for knee oa.

Sara Freeman writing for Rheumatology News reported that a study performed at Tufts University showed that tai chi is as effective as standard physical therapy in reducing pain and improving physical function according to a double blind controlled analysis. This benefit did not vary among the four tai chi instructors.

Comment: Pretty interesting item I think.

Can pinning joints work for knee osteoarthritis? Next

Joint distraction may prevent need for knee replacement in patients with knee OA

Sara Freeman writing for rheumatology news reported that joint distraction which involves temporarily pinning the knee to relieve mechanical stress may help patients void the need for knee replacement. The study, conducted at the University Medical Center Utrecht and Sint Maartenskliniek in Woerden in the Netherlands showed this procedure may be extremely valuable, particularly in younger individuals.

My comment: Unloading the joint is crucial to slowing down the progression of osteoarthritis of the knee.

Could your diabetes medicine be causing your arthritis? Next

DPP-4 Inhibitors for Diabetes Can Cause Severe Joint Pain, FDA Says

Robert Lowes writing for Medscape reported dipeptidyl peptidase-4 (DPP-4) inhibitors for type 2 diabetes may cause joint pain so intense it is disabling, the US Food and Drug Administration (FDA) warned today.

Fortunately, the pain goes away, usually in less than a month, once patients stop taking the medicine.

The agency said it identified 33 cases of severe joint pains associated with DPP-4 inhibitors from October 16, 2006, through December 31, 2013, in its FDA Adverse Event Reporting System database. Twenty-eight of the cases involved sitagliptin (Januvia, Merck & Co, Inc). Sitagliptin accounts for more than 80% of all DPP-4 prescriptions in the country, according to a spokesperson for Merck.

Saxagliptin (Onglyza, AstraZeneca), linagliptin (Tradjenta, Boehringer Ingelheim Pharmaceuticals), alogliptin (Nesina, Takeda Pharmaceutical Company), and vildagliptin, which is not marketed in the United States, accounted for the rest of the 33 cases.

Comment: Wow… I didn’t know that.

Newts for arthritis? Next…

How newts can help osteoarthritis patients

Reported in Medical Xpress, a research team at York has adapted the astonishing capacity of animals such as newts to regenerate lost tissues and organs caused when they have a limb severed.

The scientists, led by Dr Paul Genever in the Arthritis Research UK Tissue Engineering Centre in the University’s Department of Biology, have developed a technique to rejuvenate cells from older people with osteoarthritis to repair worn or damaged cartilage thus reducing pain.

A patient’s own bone marrow stem cells are, however, a valuable source of potential treatment as they can generate joint tissue the body will not reject when re-implanted. Nevertheless, as people grow older the number of stem cells decreases and those that remain are less able to grow and repair tissue.

Cells in newts can change in response to injury—a process known as dedifferentiation. The cells aggregate and return to a stem cell-like state to allow them to increase in numbers and generate the specialized cells needed for new tissue formation

But this form of tissue regeneration does not occur in humans, so the researchers recreated similar conditions in the laboratory by growing human cells as 3D aggregates.

The research was published in Nature Scientific Reports.
Comment: Interesting stuff.

Depression Linked to CVD Risk in Rheumatoid Arthritis

Dr. Laurie Barclay writing in Medscape Rheumatology reported that depressive symptoms, stress, anger/anxiety, and level of social support may affect cardiovascular risk in patients with rheumatoid arthritis (RA), according to a longitudinal cohort study published in Arthritis Care and Research. Appropriate screening and intervention in these patients may reduce their burden of cardiovascular disease (CVD).

Comment: The increased risk of cardiovascular risk has been reported multiple times. This study appears to add a new wrinkle.

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