Osteoarthritis | Jab Halts OA Progression

http://youtu.be/z8N8tUnnCcM

A new drug to halt osteoarthritis on the horizon… next

New jab to halt wear and tear in your knee joints: Drug halts osteoarthritis progression

Roger Dobson writing in the Daily Mail reported a simple jab could be the first treatment to halt the progression of osteoarthritis.

Early studies suggest this new drug, a form of antibody, tackles the disease itself rather than the symptoms alone.

The new injection, based on antibodies from the immune system, acts on one of the key players of the condition, a compound called Interleukin-1 or IL-1. This is a cytokine – a chemical messenger for the immune system. It also has a role in inflammation.

It is thought that IL-1 gathers around joints after injury or as a result of day-to-day damage, causing inflammation and harm to the cartilage – so it may have a crucial role in the development of osteoarthritis.

It has also been suggested that IL-1 is also involved in increasing the perception of pain.

The new drug, known as  ABT-981, is an antibody that blocks the activity of the harmful cytokine and is injected into the joint area. Early animal tests have found that it can stop the disease getting worse.
Comment: It will be interesting to see if further trials support the initial hype.

 

What do you know about this devastating nursing home problem…next

Hip Fractures in Nursing Homes Often Followed By Death or Immobility.

Kathryn Doyle writing for Reuters reported that a study conducted by the Perelman School of Medicine at the University of Pennsylvania and published in JAMA Internal Medicine found that half of nursing home residents who suffered from a hip fracture would either die or be unable to walk in the six months following the injury, while resident over 90 years old were more likely to die or become completely disabled.

 

Comment: The underlying cause of course is osteoporosis.  That condition needs to be diagnosed, treated, and followed.

Another breakthrough in stem cell science… and we have lab rats to thank for it… next

Osteoarthritis in rats responds to stem cell mobilization therapy
Reported in Medical News Today, researchers in Taiwan have found that peripheral blood stem cells “mobilized” by a special preparation of granulocyte colony-stimulating factor prior to their injection into rats modeling osteoarthritis, stimulated the bone marrow to produce stem cells, leading to the inhibition of OA progression. The finding, they said, may lead to a more effective therapy for OA, a common joint disease that affects 10 percent of Americans over the age of 60.

 

Comment: More great news about stem cells and osteoarthritis.

A new method for diagnosing early rheumatoid arthritis… next

PET And SPECT Imaging Visualizes Rheumatoid Arthritis.

Reported in Diagnostic Imaging… Dutch researchers performed the study utilizing PET and SPECT to evaluate antifibroblast activation protein (FAP) antibodies, which are associated with rheumatoid arthritis (RA) inflammation. Diagnostic Imaging further reports that the researchers “concluded that the anti-FAP antibody 28H1 labeled with 89Zr or 111In showed excellent characteristics for imaging inflamed synovial tissue” and that “uptake correlated with severity of the inflammation.”

 

Comment: Interesting but not ready for prime time and definitely expensive.

Too good to be true.  And I was fooled also

Japanese stem cell breakthrough, a fraud

Reported by Rob Stein in Shots, a prestigious scientific journal took the unusual step of retracting some high-profile research that had generated international excitement about stem cell research.

The British scientific journal Nature retracted two papers published in January by scientists at the research institute in Japan that claimed that they could create induced pluripotential stem cells simply by dipping skin and blood cells into acid.

The claim raised the possibility of being able to use the cells to easily make any kind of cell in the body to treat many diseases and generated international media coverage.

But other scientists almost immediately raised questions about the papers, and investigators eventually found that the research papers contained many errors. In April, even Riken claimed that Haruko Obokata, the main Japanese scientist, was guilty of scientific misconduct.

The scientists involved in the work, including at the Harvard-affiliated Brigham and Women’s Hospital in Boston, issued statements regretting the problems with the papers and agreeing that they should be retracted.

Comment: In a previous blog video I said this was a major breakthrough.  Scientific misconduct is unfortunately all too common.

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