FDA 'Okays' Nerve Growth Factor Studies

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FDA OKs Nerve Growth Factor Studies

Emily Walker writing in MedPage Today explained that the drug makers “all agree there is a signal linking the use of anti-NGF drugs and deterioration of the joints, but they say it’s caused by patients using anti-NGF drugs along with non-steroidal anti-inflammatory drugs (NSAIDs) and have recommended that if the drugs are marketed patients not use them alongside NSAIDs.”  Panel “members agreed that the class of drugs is linked to joint destruction but said the evidence is not well-understoodon whether anti-NGF drugs cause osteonecrosis and how they interact with other drugs.”  These drugs worked too well for OA. I’m glad they’re going back into clinical trials.

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Brown Fat Burns Ordinary Fat.

Gina Kolata writing in The New York Times reported that a study in the Journal of Clinical Investigation showed that brown fat can burn ordinary fat.”  In the study, subjects were subjected to cool temperatures, and “their metabolic rates increased by 80 percent.” In addition, a previous study showed “that a second form of brown fat can be created from ordinary white fat by exercise.  What can Brown do for you?


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Postmenopausal Use Of Anti-Ulcer Drugs Increases Risk Of Hip Fracture.

Nancy Walsh writing in MedPage Today reported according to a National Institutes of Health-funded study published in the BMJ, “postmenopausal women who use proton pump inhibitors-drugs used to combat ulcers, regularly are at increased risk for hip fracture, particularly if they have ever smoked.”  In fact, “the risk of hip fracture was increased by 35 percent among women who used these drugs for at least two years, compared with women who never used them.  What’s more, “the risk for fracture rose by more than 50 percent among women with a history of smoking.

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Barry Meier writing for the New York Times reported that A year before recalling an artificial hip, an executive at Johnson & Johnson reported in an internal e-mail that the FDA had refused to approve the device, after reviewing company studies that showed it had failed prematurely in “significant” numbers, requiring repeat surgeries for patients. Meier said, “The statements in that e-mail contrast with those made by the company in recent years about the all-metal hip.  Before recalling the device amid rising failure rates in 2010, Johnson & Johnson insisted it was safe and maintained that its’ internal studies refuted complaints by surgeons and regulators abroad that the device was flawed.

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Lara Salahi and Brinda Adhikari reporting for ABC News said “In 2009, nearly 63 percent of women underwent total knee replacement surgery, most of whom were between ages of 40 and 80, according to Nationwide Inpatient Sample, a database sponsored by the Agency for Healthcare Research and Quality.”  However, even though “more than 90 percent of people who undergo total knee replacement experience a dramatic reduction in pain,” returning to “strenuous physical activities” is difficult, and “most surgeons advise against high-impact activities, such as running, jogging, jumping, and high-impact sports for the rest of one’s life after surgery.”

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